Resident Evil 4 features a completely new story and an innovative "over-the-shoulder" third person perspective that replaces the fixed camera system of the previous three Resident Evil games. Special agent Leon Kennedy is on a mission to rescue Ashley Graham, the daughter of the U.S. President, from a sinister cult in a remote rural part of Europe. Leon must fight hordes of violent villagers and mutated monsters on his way to save her.

In this run, IgorOliveira666 aims to run through the game while only using grenades to deal with enemies and bosses. Guns are only used for breaking open boxes, treasures, padlocks, etc.