The first attempt did use much more dodging, but actually simply avoiding zombies made me win frames, so i went for the fastest strategy :p
For the wurm, its the only part i would change yeah, but, you need to consider that pickup a extra powder also mean to open the menu (pickup + a few frames for mix later)
I was mislead by ZENO run, because in jap version apparently he die in 11 rounds, while here he take 12 and still need shooty + hand gun to finish him, it seem this boss at least have less hp for jap
Im realy unsure how much time i would have win, because of the pickup involved mainly
If in the pharmacy i had 3xA + 3xB i feel the run would have been better ;)
For the final boss, i can even get him hit in the first blast, but this doesnt load his death sequence (it seem it doesnt even damage him... logic somewhat since the wall still there after all), this boss dont have hps btw, but, after certain ammount of damage, he will start to go in the middle of the cannon to get shooted at, automaticly, regardless you keep damaging him or not
Unless im proven wrong i think version2 of the run is realy optimized and good candidate for tas submiting (well, when the site is fixed and accept my file lol)
About the lag/load, i think i would have win even more time if it was realy shorten, tough, need to consider the "fix" is used on 80 doors, mean near 1/3 of the doors have somewhat a difference probably
Overall i dont think it realy weighty in the balance, at most its seconds on the run, the first run was 1:12 and pretty much copycat your sda run, the gain come mainly from ultra fast menu ect... well i think
Good luck for your run :)
