How about Logitech Trackman Marble Trackball Mouse – Wired USB Ergonomic Mouse for Computers, with 4 Programmable Buttons, Dark Gray?
Would fit larger hands I believe. The thing is pretty big.
There is a button assigned to the wheel scroll functionality, it acts like the scroll.
It is wired USB.
Has 2 buttons on either side.
DPI I don't think makes sense as a measurement for this trackballs, but you can adjust the sensitivity with the trackball.
Ambi friendly. I have on occasion hurt a hand so sometimes I would switch mouse hands and this works for that. I actually have the buttons reversed so the right click is on the left side, for some reason I like that better.
Right now about $25. Not sure on how long it will last but been good for a little over a year.
The only issue I had with it was I accidentally peeled off a support rubber piece on the bottom, but even with that still good since you only need to move the trackball.
You will need to pull out the ball and clean off the lint inside every once in a while.
https://www.amazon.com/dp/B001F42MKG?tag=duckduckgo-d-20&linkCode=osi&th=1&psc=1